Enzyme Commission Number

 

What is Enzyme Commission Number?

The Enzyme commission number or “EC number” is a numerical classification scheme for enzymes based on the chemical reactions they catalyze. This system of nomenclature of enzymes was set up by International Union of Biochemistry (IUB) in consultation with the International Union of Pure and Applied Chemistry (IUPAC) in 1955.

The detailed chart of Enzyme Commission Number is given below:-

Class-1:- Oxidoreductase

1.1.–.– Acting on the CH–OH group of donors

1.  1. 1.– With NAD or NADP as acceptor

1. 1. 2.– With a cytochrome as acceptor

1. 1. 3.– With oxygen as acceptor

1. 1. 4.– With a disulfide as acceptor

1. 1. 5.– With a quinone or similar compound as acceptor

1. 1.99. – With other acceptors

1.2. –.– Acting on the aldehyde or oxo group of donors

1.  2. 1.– With NAD or NADP as acceptor

1. 2. 2.– With a cytochrome as acceptor

1. 2. 3.– With oxygen as acceptor

1. 2. 4.– With a disulfide as acceptor

1. 2. 7.– With an iron–sulfur protein as acceptor

1. 2.99.– With other acceptors

1.  3.–.– Acting on the CH–CH group of donors

1.  3. 1.– With NAD or NADP as acceptor

1. 3. 2.– With a cytochrome as acceptor

1. 3. 3.– With oxygen as acceptor

1. 3. 5.– With a quinone or related compound as acceptor

1. 3. 7.– With an iron–sulfur protein as acceptor

1. 3.99.– With other acceptors

1.  4.–.– Acting on the CH–NH₂ group   of   donors

1.  4. 1.– With NAD or NADP as acceptor

1. 4. 2.– With a cytochrome as acceptor

1. 4. 3.– With oxygen as acceptor

1. 4. 4.– With a disulfide as acceptor

1. 4. 7.– With an iron–sulfur protein as acceptor

1. 4.99.– With other acceptors

1.  5.–.– Acting on the CH–NH group of donors

1.  5. 1.– With NAD or NADP as acceptor

1. 5. 3.– With oxygen as acceptor

1. 5. 4.– With a disulfide as acceptor

1. 5. 5.– With a quinone or similar compound as acceptor

1. 5.99.– With other acceptors

1.  6.–.– Acting on NADH₂ orNADPH₂

1.  6. 1.– With NAD or NADP as acceptor

1. 6. 2.– With a cytochrome as acceptor

1. 6. 4.– With a disulfide as acceptor

1. 6. 5.– With a quinone or similar compound as acceptor

1. 6. 6.– With a nitrogenous group as acceptor

1. 6. 8.– With a flavin as acceptor

1. 6.99.– With other acceptors

1.  7.–.– Acting on other nitrogenous compounds as donors

1.  7. 2.– With a cytochrome as acceptor

1. 7. 3.– With oxygen as acceptor

1. 7. 7.– With an iron–sulfur protein as acceptor

1. 7.99.– With other acceptors

 

1.  8.–.– Acting on a sulfur group of donors

1.  8. 1.– With NAD or NADP as acceptor

1. 8. 2.– With a cytochrome as acceptor

1. 8. 3.– With oxygen as acceptor

1. 8. 4.– With a disulfide as acceptor

1. 8. 5.– With a quinone or similar compound as acceptor

1. 8. 7.– With an iron–sulfur protein as acceptor

1. 8.99.– With other acceptors

1.  9.–.– Acting on a haem group of donors

1.  9. 3.– With oxygen as acceptor

1.9.6.–With a nitrogenous group as acceptor

1.  9.99.–Withotheracceptors

1.10.–.– Acting on diphenols and related substances as donors

1.10. 1.– With NAD or NADP as acceptor

1.10. 2.– With a cytochrome as acceptor

1.10.   3.– With oxygen as acceptor 1.10.99.– With other acceptors

1.11.  –.– Acting on a peroxide as acceptor (peroxidases) 1.11.1.–Asinglesubclasscontainingtheperoxidases

1.12.  –.– Acting on hydrogen asdonor

1.12. 1.– With NAD or NADP as acceptor

1.12.   2.– With a cytochrome asacceptor 1.12.99.– With otheracceptors

1.13.  –.–Acting on single donor within corporation of molecular oxygen

1.14.  1.13.11.– With incorporation of two atoms ofoxygen

1.13.12.– With incorporation of one atom of oxygen 1.13.99.– Miscellaneous (requires further characterization)

1.15.  –.– Acting on paired donors with incorporation of molecularoxygen

1.14.11.–With2-oxoglutarateasonedonor,andincorporationofoneatomeachofoxygenintobothdonors 1.14.12.–WithNADH₂orNADPH₂asonedonor,andincorporationoftwoatomsofoxygenintoonedonor 1.14.13.–WithNADH₂orNADPH₂asonedonor,andincorporationofoneatomofoxygen

1.14.14.–Withreducedflavinorflavoproteinasonedonor,andincorporationofoneatomofoxygen 1.14.15.–Withareducediron–sulfurproteinasonedonor,andincorporationofoneatomofoxygen 1.14.16.– With reduced pteridine as one donor, and incorporation of one atom ofoxygen

1.14.17.– With ascorbate as one donor, and incorporation of one atom of oxygen 1.14.18.– With another compound as one donor, and incorporation of one atom of oxygen 1.14.99.– Miscellaneous (requires further characterization)

1.16.  –.– Acting on superoxide radicals asacceptor 1.16.–.– Oxidizing metalions

1.17.   1.– With NAD or NADP as acceptor

1.16.   3.– With oxygen asacceptor 1.17.–.– Acting on –CH₂–groups

1.17.   1.– With NAD or NADP as acceptor

1.17. 3.– With oxygen as acceptor

1.17.   4.– With a disulfide asacceptor 1.17.99.– With otheracceptors

1.18.  –.– Acting on reduced ferredoxin asdonor

1.18. 1.– With NAD or NADPasacceptor

1.18.   6.– With dinitrogen asacceptor 1.18.99.– With H+ asacceptor

1.19.  –.– Acting on reduced flavodoxin asdonor

1.20.   6.– With dinitrogen asacceptor 

1.97.–.– Otheroxidoreductases

 

Class-2 :-  Transferase

2.  1. –.– Transferring one-carbon groups

2. 1. 1. – Methyltransferases

2. 1. 2. – Hydroxymethyl-, formyl- and related transferases

2. 1. 3. – Carboxyl- and carbamoyltransferases

2. 1. 4. – Amidinotransferases

2. 2. –.– Transferring aldehyde or ketone residues

2.2.1.–A single subclass containing the transaldolases and transketolases

2. 3. –.– Acyltransferases  

2. 3. 1. – Acyltransferases

2. 3. 2. – Aminoacyltransferases

2. 4. –.– Glycosyltransferases

2. 4.  1. –Hexosyltransferases

2. 4.  2. –Pentosyltransferases

2. 4.99. – Transferring other glycosyl groups

2.5.–.–Transferring alkyl or aryl groups, other than methyl groups

2. 5. 1. – A single subclass that includes a rather mixed group of such enzymes

2. 6. –.– Transferring nitrogenous groups

2. 6. 1. – Transaminases (aminotransferases)

2. 6. 3. – Oximinotransferases

2. 6.99. – Transferring other nitrogenous groups

2. 7. –.– Transferring phosphorus-containing groups

2. 7. 1. – Phosphotransferases with an alcohol group as acceptor

2.7.2.–Phosphotransferases with a carboxyl group as acceptor

2.7.3.–Phosphotransferases with a nitrogenous group as acceptor

2. 7.4. – Phosphotransferases with a phosphate group as acceptor

2. 7.  6. – Diphospho transferases

2. 7.  7. –Nucleotidyl transferases

2. 7. 8. – Transferases for other substituted phosphate groups

2. 7. 9. – Phosphotransferases with paired acceptors

2. 8. –.– Transferring sulfur-containing groups

2. 8. 1. – Sulfur transferases

2. 8.  2. –Sulfotransferases

2. 8.  3. –CoA-transferases

2.  9. –.– Transferring selenium-containing groups

 

Class-3 :- Hydrolases

3.  1. –.– Acting on ester bonds

3.1.  1. – Carboxylic ester hydrolases

3.1. 2. – Thiol ester hydrolases

3.1. 3. – Phosphoric monoester hydrolases

3.1. 4. – Phosphoric diester hydrolases

3.1. 5. – Triphosphoric monoester hydrolases

3.1. 6. – Sulfuric ester hydrolases

3.1. 7. – Diphosphoric monoester hydrolases

3.1.  8. – Phosphoric triesterhydrolases

3.1.11. – Exodeoxyribonucleases producing 5-phosphomonoesters

3.1.13.  – Exoribonucleases producing 5-phosphomonoesters

3.1.14.  – Exoribonucleases producing other than5-phosphomonoesters

3.1.15.   Exonucleases active with either ribo- or deoxyribonucleic acids and producing5-phosphomonoesters

3.1.16.  – Exonucleases active with either ribo- or deoxyribonucleic acids and producing other than5-phosphomonoesters

3.1.21.  – Endodeoxyribonucleases producing5-phosphomonoesters

3.1.22.  – Endodeoxyribonucleases producing other than5-phosphomonoesters

3.1.25.  – Site-specific endodeoxyribonucleases specific for altered bases

3.1.26.  – Endoribonucleases producing 5-phosphomonoesters

3.1.27.  – Endoribonucleases producing other than5-phosphomonoesters

3.1.30.  – Endonucleases active with either ribo- or deoxyribonucleic acid and producing5-phosphomonoesters

3.1.31.  – Endonucleases active with either ribo- or deoxyribonucleic acid and producing other than5-phosphomonoesters

3. 2. –.– Glycosidases

3.2.  1. – Hydrolysing O-glycosyl compounds

3.2. 2. – Hydrolysing N-glycosyl compounds

3.2.  3. – Hydrolysing S-glycosyl compounds

3. 3. –.– Acting on ether bonds

3.3.  1. – Thio ether hydrolases

3.3. 2. – Ether hydrolases

3. 4. –.– Acting on peptide bonds (peptidase)

3.4.11. – Aminopeptidases

3.4.13.  – Dipeptidases

3.4.14.  – Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.15.  – Peptidyl-dipeptidases

3.4.16.  – Serine-type carboxypeptidases

3.4.17.  – Metallo carboxypeptidases

3.4.18.  – Cysteine-type carboxypeptidases

3.4.19.  – Omega peptidases

3.4.21.  – Serine endopeptidases

3.4.22.  – Cysteine endopeptidases

3.4.23.  – Aspartic endopeptidases

3.4.24.  – Metallo endopeptidases

3.4.99. – Endopeptidases of unknown catalytic mechanism

3. 5. –.– Acting on carbon–nitrogen bonds, other than peptide bonds

3.5. 1. –  In linear amides

3.5. 2. –  In cyclic amides

3.5. 3. –  In linear amidines

3.5. 4. –  In cyclic amidines

3.5. 5. – In nitriles

3.5.99. – In other compounds

3. 6. –.– Acting on acid anhydrides

3.6. 1. – In phosphorus-containing anhydrides

3.6.  2. – In sulfonyl-containing anhydrides

3. 7. –.– Acting on carbon–carbon bonds

3.7.  1. – In ketonic substances

3. 8. –.– Acting on halide bonds

3.8.  1. – In C-halide compounds

3.  9. –.– Acting on phosphorus–nitrogen bonds

3.10. –.– Acting on sulfur–nitrogen bonds

3.11. –.– Acting on carbon–phosphorus bonds

3.12. –.– Acting on sulfur–sulfur bonds

 

 

Class-4 :- Lyases

4. 1. –.– Carbon–carbon lyases

4. 1. 1 – Carboxy-lyases

4. 1. 2 – Aldehyde-lyases

4. 1. 3 – Oxo-acid-lyases

4. 1.99 – Other carbon–carbon lyases

4. 2. –.– Carbon–oxygen lyases

4. 2. 1 – Hydro-lyases

4. 2. 2 – Acting on polysaccharides

4. 2.99 – Other carbon–oxygen lyases

4. 3. –.– Carbon–nitrogen lyases

4. 3. 1 – Ammonia-lyases

4. 3. 2 – Amidine-lyases

4. 3. 3 – Amine-lyases

4. 3.99 – Other carbon–nitrogen-lyases

4. 4. –.– Carbon–sulfur lyases

4. 5. –.– Carbon–halide lyases

4.6. –.– Phosphorus-oxygen lyases

4.99. –.– Other lyases

 

 

Class-5 :- Isomerase

4.1. –.– Racemases and epimerases

5. 1. 1. – Acting on amino acids and derivatives

5. 1. 2. –  Acting on hydroxy acids and derivatives

5. 1. 3. –  Acting on carbohydrates and derivatives

5. 1.99. – Acting on other compounds

5. 2. –.– cis–trans-Isomerases

5. 3. –.– Intramolecular oxidoreductases

5. 3. 1. – Interconverting aldoses and ketoses

5. 3. 2. – Interconverting keto- and enol-groups

5. 3. 3. – Transposing C-C bonds

5. 3. 4. – Transposing S–S bonds

5. 3.99. – Other intramolecular oxidoreductases

5. 4. –.– Intramolecular transferases (mutases)

5. 4. 1. – Transferring acyl groups

5. 4. 2. – Phosphotransferases (phosphomutases)

5. 4. 3. – Transferring amino groups

5. 4.99. – Transferring other groups

5.  5. –.– Intramolecular lyases

5.99. –.– Other isomerases

 

 

 

Class-6 :- Ligases

5.  1. –.– Forming carbon–oxygen bonds

6. 1. 1. – Ligases forming aminoacyl-tRNA and related compounds

6. 2. –.– Forming carbon–sulfur bonds

6. 2. 1. – Acid–thiol ligases

6. 3. –.– Forming carbon–nitrogen bonds

6. 3. 1. – Acid–ammonia (or amine) ligases (amide synthases)

6. 3. 2. – Acid–amino-acid ligases (peptide synthases)

6. 3. 3. – Cyclo-ligases

6. 3. 4. – Other carbon–nitrogen ligases

6. 3. 5. – Carbon–nitrogen ligases with glutamine as amino-N-donor

6. 4. –.– Forming carbon–carbon bonds

6. 5. –.– Forming phosphoric ester bonds